The SNHG3/miR-148a-3p axis-mediated high expression of DNMT1 is correlated with poor prognosis and tumor immune infiltration in hepatocellular carcinoma

Abstract Background: Epigenetic reprogramming, particularly DNA methylation mediated by DNA-methyltransferase 1 (DNMT1), plays a crucial role in the pathogenesis of hepatocellular carcinoma (HCC). However, the regulatory mechanisms underlying DNMT1 overexpression and its relationship with immune infiltration in HCC remain unclear. This study aimed to investigate the expression pattern, prognostic significance, and regulatory network of DNMT1 in HCC, as well as its correlation with the tumor immune microenvironment. Methods: A pan-cancer analysis of DNMT1 expression and prognosis was conducted using The