Prognostic and immunotherapeutic significance of NCAPD2 in pan-cancer and its role in hepatocellular carcinoma progression via the AKT/GSK-3β signaling pathway

Abstract Present studies indicated that NCAPD2 (Non-SMC condensin I complex subunit D2) has emerged as an essential participant of condensin I involved in the mitotic chromosome assembly and dissociation. However, its comprehensive role in pan-cancer and its underlying mechanisms remain underexplored. This study systematically analyzed NCAPD2’s prognostic significance, functional mechanisms, and immune infiltration correlations in pan-cancer, with a focus on hepatocellular carcinoma (HCC). Using databases such as TCGA, TIMER2.0, and HPA, we evaluated NCAPD2’s association with oncogenesis, prognosis, methylation, and