Intramolecular Dynamics within the N-Cap-SH3-SH2 Regulatory Unit of the c-Abl Tyrosine Kinase Reveal Targeting to the Cellular Membrane*♦

Abstract Background: c-Abl regulates cell signaling and participates in leukemia pathogenesis via Bcr-Abl chimeric protein. Results: N-Cap and SH3 residues acquire μs-ms motions within the regulatory unit and membrane anchoring upon protein activation. Conclusion: N-Cap-myristoyl tether triggers c-Abl to anchor membrane because of μs-ms dynamics within this regulatory region. Significance: Binding to the membrane is lost in Bcr-Abl chimeric protein, which underlies leukemia. Article type: Research Article Keywords: NMR, Protein Dynamics, Protein Structure, Tyrosine Protein Kinase (Tyrosine Kinase), X-ray Scattering,