Bioactive Alkaloids from Nepalese Corydalis chaerophylla D.C. Acting on the Regulation of PCSK9 and LDL‐R In Vitro

Abstract Four new alkaloids Chaeronepaline‐A (1), Chaeronepaline‐B (2), Chaeronepaline‐C (3), and Chaeronepaline‐D (4) were isolated from Corydalis chaerophylla D.C. collected from Nepal and their structures were elucidated by spectroscopic data, 1D, 2D NMR and mass spectrometry. The structures were established as 3,12‐ Dimethoxy‐5,6‐dihydroisoquinolino [2,1‐b] isoquinolin‐ 7‐ ium‐ 2, 9‐ diol (1), 7‐Methyl‐2,3 : 11,12‐bis(methylenedioxy)‐7,13a‐secoberbin‐13–14‐epoxide (2), 7‐ methyl‐5, 6, 7, 8‐ tetrahydro‐ 8H‐spiro‐9,14‐dihydroxy‐11,12‐methylenedioxy‐indane‐isoquinoline (3) and 7‐ methyl‐5, 6, 7, 8‐ tetrahydro‐ 8H‐spiro‐9,14‐dihydroxy‐11,12‐methylenedioxy‐indane‐isoquinoline‐N‐oxide (4). The new alkaloids were tested in human hepatoma