https://doi.org/10.1002/14651858.CD010216.pub10
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|
Study ID |
Study design |
Intervention/ comparator |
Time point |
Data (SAEs) |
Between group difference (RCT) (↑ more SAEs in intervention arm; ↔ equivocal; ↓ fewer SAEs in intervention arm)
Direction over time (cohort) (↓ decline in frequency) |
|
Edwards 2023 |
Cohort |
Nicotine EC |
6 months |
No serious adverse events or expeditable events occurred.
|
|
|
Bullen 2013 |
RCT |
Nicotine EC v non-nicotine EC v NRT |
6 months |
None occurred which were considered related to study treatment. No further information available. |
|
|
Caponnetto 2013b* |
Cohort |
Nicotine EC |
1 year |
None occurred |
|
|
Caponnetto 2021* |
Cohort |
Nicotine EC |
24 weeks |
None occurred |
|
|
Hickling 2019 |
Cohort |
Nicotine EC |
6 weeks |
(Recruited from mental health settings) Five SAEs during study; all were psychiatric hospitalisations; all were considered unrelated to the study intervention |
|
|
Higgins 2024 |
RCT |
nicotine EC + very low nicotine content cigarettes (VLNC) v VLNC |
16 weeks |
One SAE related or probably related to study product in EC plus VLNC arm. None in VLNC alone arm. |
↑ |
|
Humair 2014 |
Cohort |
Nicotine EC |
Unclear (longest follow-up 1 year) |
None reported |
|
|
Dawkins 2020 |
RCT |
Nicotine EC v usual care |
24 weeks |
Not formally assessed. A&E visits reported: “low but constant use of emergency and hospital services in both arms. Usual care (n= 32), 4-7 participants visited A & E at different time points. The number of visits ranged from one to nine times. In the EC arm (n =48), 5-7 participants visited A & E at different time points. The number of visits ranged from one to six times.” “in the UC arm, at least five participants at baseline, two at 4 weeks, one at 12 weeks and one at 24 weeks were admitted following the A & E visit. In the EC arm, at least two participants at baseline, three at 4 weeks, and one at 12 weeks were admitted following the A & E visit.” |
↔ |
|
Kanobe 2022* |
Cohort |
Nicotine EC |
|
None reported |
|
|
Morris 2022* |
RCT |
Nicotine EC, variations on nicotine strength, flavour, and salt vs. freebase |
9 days |
None occurred |
|
|
NCT02648178 |
Cohort |
Nicotine EC |
NS |
Reports 1 event (death) (n = 19). No further detail provided. |
|
|
Polosa 2011* |
Cohort |
Nicotine EC |
6 months |
None occurred during the study |
|
|
Sifat 2024 |
RCT |
Nicotine EC v nicotine EC + incentives |
8 weeks |
None reported |
|
|
Valentine 2018 |
Cohort |
Nicotine EC |
8 weeks |
“No serious adverse events were reported” |
|