Pancreatic cancer cachexia: a review of mechanisms and therapeutics
Abstract Over the last decade, we have gained new insight into the pathophysiology of cachexia associated with pancreatic cancer. Unfortunately,…
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Chemogenomics knowledgebased polypharmacology analyses of drug abuse related G-protein coupled receptors and their ligands
Abstract Drug abuse (DA) and addiction is a complex illness, broadly viewed as a neurobiological impairment with genetic and environmental…
Effects of cannabinoid drugs on the deficit of prepulse inhibition of startle in an animal model of schizophrenia: the SHR strain
Abstract Clinical and neurobiological findings suggest that the cannabinoids and the endocannabinoid system may be implicated in the pathophysiology and…
CANABIC: CANnabis and Adolescents: effect of a Brief Intervention on their Consumption – study protocol for a randomized controlled trial
Abstract Background: Cannabis is the most consumed illegal substance in France. General practitioners (GPs) are the health professionals who are…
The cannabinoid receptor 1 associates with NMDA receptors to produce glutamatergic hypofunction: implications in psychosis and schizophrenia
Abstract The endocannabinoid system is widespread throughout the central nervous system and its type 1 receptor (CB1) plays a crucial…
Δ9-THC and N-arachidonoyl glycine regulate BV-2 microglial morphology and cytokine release plasticity: implications for signaling at GPR18
Abstract Microglial cells are extremely plastic and undergo a variety of CNS-prompted shape changes relative to their location and current…
Cannabinoid-hypocretin cross-talk in the central nervous system: what we know so far
Abstract Emerging findings suggest the existence of a cross-talk between hypocretinergic and endocannabinoid systems. Although few studies have examined this…
The Endocannabinoid System and Spermatogenesis
Abstract Spermatogenesis is a complex process in which male germ cells undergo a mitotic phase followed by meiosis and by…
The effects of caffeine, nicotine, ethanol, and tetrahydrocannabinol on exercise performance
Abstract Caffeine, nicotine, ethanol and tetrahydrocannabinol (THC) are among the most prevalent and culturally accepted drugs in western society. For…
Multiple sclerosis-induced neuropathic pain: pharmacological management and pathophysiological insights from rodent EAE models
Abstract In patients with multiple sclerosis (MS), pain is a frequent and disabling symptom. The prevalence is in the range…