Dopamine in the Brain: Hypothesizing Surfeit or Deficit Links to Reward and Addiction
Abstract Recently there has been debate concerning the role of brain dopamine in reward and addiction. David Nutt and associates…
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A new formulation of cannabidiol in cream shows therapeutic effects in a mouse model of experimental autoimmune encephalomyelitis
Abstract Background: The present study was designed to investigate the efficacy of a new formulation of alone, purified cannabidiol (CBD)…
Crosstalk between endocannabinoid and immune systems: a potential dysregulation in depression?
Abstract Background: The endocannabinoid (eCB) system, an endogenous lipid signaling system, appears to be dysregulated in depression. The role of…
Finding cannabinoids in hair does not prove cannabis consumption
Abstract Hair analysis for cannabinoids is extensively applied in workplace drug testing and in child protection cases, although valid data…
Plant derived substances with anti-cancer activity: from folklore to practice
Abstract Plants have had an essential role in the folklore of ancient cultures. In addition to the use as food…
Atypical course in severe catatonic schizophrenia in a cannabis-dependent male adolescent: a case report
Abstract Introduction: Adolescents with psychoses usually have full recovery from their first psychotic episode, but the first relapse often arises…
Distinguishing cognitive state with multifractal complexity of hippocampal interspike interval sequences
Abstract Fractality, represented as self-similar repeating patterns, is ubiquitous in nature and the brain. Dynamic patterns of hippocampal spike trains…
Cannabinoid Ligands and Alcohol Addiction: A Promising Therapeutic Tool or a Humbug?
Abstract The vast therapeutic potential of cannabinoids of both synthetic and plant-derived origins currently makes these compounds the focus of…
Cannabinoid-based drugs targeting CB1 and TRPV1, the sympathetic nervous system, and arthritis
Abstract Chronic inflammation in rheumatoid arthritis (RA) is accompanied by activation of the sympathetic nervous system, which can support the…
Discovery and resupply of pharmacologically active plant-derived natural products: A review
Abstract Medicinal plants have historically proven their value as a source of molecules with therapeutic potential, and nowadays still represent…