To Act or Not to Act: Endocannabinoid/Dopamine Interactions in Decision-Making
Abstract Decision-making is an ethologically adaptive construct that is impaired in multiple psychiatric disorders. Activity within the mesocorticolimbic dopamine system…
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Cannabis and cocaine decrease cognitive impulse control and functional corticostriatal connectivity in drug users with low activity DBH genotypes
Abstract The dopamine β-hydroxylase (DβH) enzyme transforms dopamine into noradrenaline. We hypothesized that individuals with low activity DBH genotypes (rs1611115…
Learning, Memory, and Executive Function in New MDMA Users: A 2-Year Follow-Up Study
Abstract 3,4-Methylenedioxymethamphetamine (MDMA) is associated with changes in neurocognitive performance. Recent studies in laboratory animals have provided additional support for…
Acceptability and utility of an electronic psychosocial assessment (myAssessment) to increase self-disclosure in youth mental healthcare: a quasi-experimental study
Abstract Background: Technology is increasingly being used in youth mental healthcare to support service delivery and improve health outcomes. The…
Acute effects of cocaine and cannabis on reversal learning as a function of COMT and DRD2 genotype
Abstract Rationale: Long-term cannabis and cocaine use has been associated with impairments in reversal learning. However, how acute cannabis and…
Sex differences in substance use, health, and social functioning among opioid users receiving methadone treatment: a multicenter cohort study
Abstract Background: Despite the growing numbers of men and women with opioid use disorder in Canada, sex-specific issues in treatment…
Role of GPR55 during Axon Growth and Target Innervation
Abstract Guidance molecules regulate the navigation of retinal ganglion cell (RGC) projections toward targets in the visual thalamus. In this…
Functional Connectivity Disruption in Neonates with Prenatal Marijuana Exposure
Abstract Prenatal marijuana exposure (PME) is linked to neurobehavioral and cognitive impairments; however, findings in childhood and adolescence are inconsistent.…
Hypothalamic control of brown adipose tissue thermogenesis
Abstract It has long been known, in large part from animal studies, that the control of brown adipose tissue (BAT)…
HIV-1, methamphetamine and astrocytes at neuroinflammatory Crossroads
Abstract As a popular psychostimulant, methamphetamine (METH) use leads to long-lasting, strong euphoric effects. While METH abuse is common in…