Supplementary material 14 to: Electronic cigarettes for smoking cessation

Lindson N, Livingstone-Banks J, Butler AR, McRobbie H, Bullen CR, Hajek P, Wu AD, Begh R, Theodoulou A, Ma C, Notley C, Rigotti NA, Turner T, Fanshawe T, Hartmann-Boyce J
https://doi.org/10.1002/14651858.CD010216.pub11

The material in this section has been supplied by the author(s) for publication under a Licence for Publication and the author(s) are solely responsible for the material. Cochrane has reviewed this material, but Cochrane has not copyedited, formatted or proofread. Cochrane accordingly gives no representations or warranties of any kind in relation to, and accepts no liability for any reliance on or use of, such material.

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Blood pressure data not contributing to meta-analyses

Study ID

Intervention/ comparator

Time point

Data

Between group difference[1] (↑ higher in EC/higher dose EC arm; ↔ equivocal; ↓ lower in EC/higher dose arm)

Caponnetto 2023*

Nicotine EC v heated tobacco

12 weeks

“No significant changes in the mean resting heart rate, blood pressure, and BMI during product use were observed between and within study groups.”

↔

Cioe 2025

Nicotine EC v behavioural support

6 weeks

"We observed a significant group by time interaction in systolic blood pressure which was driven by decreasing systolic blood pressure in the experimental condition and no meaningful change in the control group.."

↓

Cravo 2016*

Nicotine EC versus conventional cigarette

2 weeks

“No clinically significant changes”

NE

George 2019

Nicotine EC v non-nicotine EC

4 weeks

“When both EC groups were combined, there was a greater reduction in systolic blood pressure in the EC group than in the TC group, both in smokers of ≤20 pack-years (EC: -4.41 mm Hg; 95% CI: -7.91 to -0.91 vs. TC: -2.86 mm Hg; 95% CI: -8.09 to 2.38; p = 0.59) and >20 pack-years (EC: -7.75 mm Hg; 95% CI: -11.56 to -3.93 vs. TC: -1.37 mm Hg; 95% CI: -5.32 to 2.59; p = 0.04).”

NE

Katz 2025

Nicotine EC versus conventional cigarette

2 weeks

“Diastolic blood pressure, the only cardiac measure that significantly changed across phases (F(2,41) = 3.54, p = 0.038), was lower after the e-cigarette phase than after the cigarette phase (p = 0.03).”

↓

[1] NE: not estimable