Supplementary material 13 to: Electronic cigarettes for smoking cessation

Lindson N, Livingstone-Banks J, Butler AR, McRobbie H, Bullen CR, Hajek P, Wu AD, Begh R, Theodoulou A, Ma C, Notley C, Rigotti NA, Turner T, Fanshawe T, Hartmann-Boyce J
https://doi.org/10.1002/14651858.CD010216.pub11

The material in this section has been supplied by the author(s) for publication under a Licence for Publication and the author(s) are solely responsible for the material. Cochrane has reviewed this material, but Cochrane has not copyedited, formatted or proofread. Cochrane accordingly gives no representations or warranties of any kind in relation to, and accepts no liability for any reliance on or use of, such material.

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Heart rate data not contributing to meta-analyses

Study ID

Intervention/ comparator

Time point

Data

Between group difference[1] (↑ higher in EC/higher dose EC arm; ↔ equivocal; ↓ lower in EC/higher dose arm)

Caponnetto 2023*

Nicotine EC v heated tobacco

12 weeks

“No significant changes in the mean resting heart rate, blood pressure, and BMI during product use were observed between and within study groups.”

↔

Cioe 2025

Nicotine EC v behavioural support

6 weeks

No significant difference in heart rate between conditions.

↔

Cravo 2016*

Nicotine EC versus combustible cigarettes

2 weeks

“no clinically significant changes”

NE

George 2019

Nicotine EC v non-nicotine EC

4 weeks

“No significant trend in difference among the three arms”

Broke down results by smoking characteristics at baseline. Smoked ≤ 20 pack years (n = 31): increased by 2.6 beats/min (95% CI: 0.3 to 5.0) for EC-nicotine; 5.2 beats/min (95% CI: 0.6 to 10.0) for nicotine-free. >20 pack-years (n = 82): decreased by 2.8 beats/min (95% CI: -5.2 to -0.4) for EC nicotine; decreased by 5.6 beats/min (95% CI: -10.4 to -0.8) for no-nicotine EC

↔

[1] NE: not estimable