Supplementary material 15 to: Electronic cigarettes for smoking cessation

Lindson N, Livingstone-Banks J, Butler AR, McRobbie H, Bullen CR, Hajek P, Wu AD, Begh R, Theodoulou A, Ma C, Notley C, Rigotti NA, Turner T, Fanshawe T, Hartmann-Boyce J
https://doi.org/10.1002/14651858.CD010216.pub11

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Data on known toxicants/carcinogens from studies not contributing to meta-analyses

Study ID

Intervention / Comparator

Time point

Data

Direction over time (↓ decline; ↔ equivocal; ↑ increase)

Czoli 2019

Nicotine EC v combustible cigarettes

1 week

Compared to dual use (baseline):

1-HOP EC -31%; tobacco cigarette +23%

NNAL EC -30%; tobacco cigarette +8%

↓ 1-HOP

↓ NNAL

Ikonomidis 2020b

Nicotine EC v combustible cigarettes

1 month

“…reduction of MDA (1.22 ± 0.1 vs 1.09 ± 0.1 μmol/L, P = 0.03)” in EC group. No change reported in cig group

↓MDA

Pratt 2022

Nicotine EC v no intervention

8 weeks

“NNAL decreased more over time in the e-cigarette group. Closer examination of the longitudinal differences in NNAL revealed that the e-cigarette group had significantly lower NNAL at 4 weeks (estimate=0.54; se=0.23; t=2.37;p<.02), but the group difference was attenuated at 8 weeks (estimate=0.42; se=0.23; t=1.83; p<.07)”

↓ NNAL